![]() In patients with AA, attack of the hair follicle is thought to be directed at autoantigens in the follicle, mediated by disruption of its immune privilege, with both melanocyte and keratinocyte-related autoantigens being proposed. In unaffected individuals, hair follicles have an immune privilege that is protective against autoimmunity. ![]() ![]() Dysregulation of several pathways immune-mediated pathways has been implicated in the development of AA, occurring in susceptible patients often with concurrent multigenetic predisposition and environmental triggers.
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